Frequently Asked Questions | Prometheuz

Question 1

What is Prometheuz?

Accepted Answer

Prometheuz is a telehealth platform that connects American men with US-licensed clinicians for lab-based testosterone evaluation and TRT. After you complete a free health assessment, you're matched with a licensed clinician who reviews your full hormone panel and health history before recommending anything. TRT is only prescribed when your bloodwork and symptoms both confirm it's clinically appropriate. We're LegitScript verified, HIPAA-compliant, and available in all 50 states.

Question 2

How do I get started?

Accepted Answer

Start with the free online health assessment. No credit card required. Once you complete it, you'll get access to your private patient portal. From there, you choose your membership plan, get your lab order, head to a lab near you for a blood draw, and book your clinician visit once your results are in. The whole process from assessment to first clinician visit takes about two weeks.

Question 3

Is Prometheuz available in my state?

Accepted Answer

Yes. Prometheuz operates across all 50 US states through a network of US-licensed clinicians. After your assessment, you'll be matched with a licensed provider who is authorized to practice in your state. If you have a specific question about your state's telehealth regulations, contact us at support@prometheuz.com.

Question 4

Is Prometheuz a legitimate medical clinic?

Accepted Answer

Prometheuz is a LegitScript-certified telehealth platform (the same verification standard used by major pharmacy chains). All clinical care is delivered by independent, licensed physicians and nurse practitioners operating under state medical board oversight. We require bloodwork before any prescription is written, follow Endocrine Society and AUA clinical guidelines, and maintain full HIPAA compliance. No prescription is issued without a clinician reviewing your labs and health history first.

Question 5

What is TRT?

Accepted Answer

Testosterone Replacement Therapy is a prescription treatment that brings clinically low testosterone back to a healthy range for your age. After your mid-30s, testosterone drops about 1 to 2 percent per year, slowly enough that most men don't connect the dots until the symptoms stack up. TRT addresses that decline when bloodwork confirms it's the cause. It's a long-term medical commitment, not a quick fix, and it requires ongoing monitoring to stay safe and effective.

Question 6

How do I know if I need TRT?

Accepted Answer

You don't know until you get tested. Fatigue, low libido, brain fog, belly fat that won't move, and a short fuse can all be symptoms of low testosterone. But they can also be caused by sleep apnea, thyroid problems, stress, or depression. The only way to find out is a full hormone panel read by a clinician who knows what they're looking at. A symptom list alone isn't a diagnosis.

Question 7

How long does TRT take to work?

Accepted Answer

Most men notice improvements in energy and mood within two to four weeks. Libido typically picks up around weeks four to six. Strength and body composition changes (leaner waist, better gym response) usually show up around the three-month mark. Full benefits take six to twelve months of consistent treatment and monitoring. Results vary by individual, and your clinician tracks your progress through quarterly labs.

Question 8

Is TRT safe?

Accepted Answer

Yes, for men with confirmed low testosterone and proper monitoring. The 2023 TRAVERSE trial (the largest cardiovascular safety study of TRT ever conducted) tracked over 5,200 men with high cardiac risk and found no higher rate of heart attacks or strokes compared to men not on TRT. In February 2025, the FDA removed the cardiovascular black box warning from all testosterone products based on that data. Safety on TRT comes from the monitoring: quarterly labs that check your testosterone, estradiol, PSA, and hematocrit keep everything in the right range.

Question 9

Can TRT affect my fertility?

Accepted Answer

Yes. This is worth knowing before you start. Testosterone from outside the body suppresses your own production, which reduces sperm count while you're on it. If having kids is on your radar, tell your clinician before treatment begins. There are alternative protocols using enclomiphene or hCG that address low testosterone symptoms without shutting down sperm production. Your clinician will go over the right option for your situation.

Question 10

Is this a treatment?

Accepted Answer

Yes, but not an automatic one. Testosterone replacement therapy is a prescription treatment for clinically confirmed low testosterone. Everyone goes through intake, labs, and clinician review first, so you only start TRT if your labs and symptoms actually support it, not because you selected it as an option.

Question 11

Can I combine TRT with another Prometheuz care path?

Accepted Answer

Sometimes. GLP-1 medication and TRT, for example, aren't mutually exclusive, since low testosterone and weight can both influence each other. Your clinician reviews both care paths together during intake to check for interactions and to sequence treatment sensibly, rather than starting everything at once.

Question 12

How long should I use it?

Accepted Answer

There's no built-in end date. Many patients require ongoing therapy because testosterone levels may decline after treatment is discontinued, although recovery varies depending on the underlying cause and individual factors. Your clinician reassesses your labs and symptoms at each follow-up to decide whether to continue, adjust the dose, or reconsider the plan entirely.

Question 13

Can I take this with medication?

Accepted Answer

Often, yes, but it depends on what you're taking. Your clinician reviews your current medications during intake specifically to flag interactions, for example with blood thinners or medications that affect red blood cell counts, before confirming your treatment plan.

Question 14

Do I automatically get GLP-1 medication after the assessment?

Accepted Answer

No. A US-licensed clinician reviews your health history and labs if needed before anything gets prescribed. If it's appropriate, they'll recommend a specific option. If not, they'll explain why.

Question 15

Is compounded semaglutide or tirzepatide FDA-approved?

Accepted Answer

No. Only branded versions like Wegovy and Zepbound are FDA-approved. Compounded versions are prepared by a licensed 503A pharmacy and are prescribed only when a documented individual clinical reason supports it, consistent with current FDA policy.

Question 16

How much weight can I expect to lose?

Accepted Answer

This varies significantly by individual, dose, and adherence to the program. There's no fixed number your clinician can promise.

Question 17

Are there side effects?

Accepted Answer

Nausea, constipation, and digestive changes are commonly reported, especially early on. Your clinician will walk you through what to expect and how to manage it.

Question 18

How does dosing work? Do I start at the full dose right away?

Accepted Answer

No. GLP-1 medications start low and increase gradually, usually every 4 weeks, to reduce side effects while your body adjusts. Your clinician manages this schedule at your follow-up visits.

Question 19

Why does tirzepatide cost more than semaglutide?

Accepted Answer

Tirzepatide is a dual GLP-1/GIP receptor agonist, a newer and more complex compound than semaglutide, which acts on the GLP-1 receptor alone. That's generally reflected in compounding and manufacturing costs.

Question 20

What happens to my weight if I stop taking GLP-1 medication?

Accepted Answer

Appetite and weight often trend back toward baseline after stopping, since the medication's effects depend on ongoing use. This is discussed with your clinician as part of your long-term plan.

Question 21

Can I switch between semaglutide and tirzepatide?

Accepted Answer

Sometimes, depending on your response and your clinician's assessment. This is discussed at follow-up visits, not decided upfront.

Question 22

What if I have a history of thyroid cancer in my family?

Accepted Answer

A personal or family history of medullary thyroid cancer or MEN2 syndrome rules out GLP-1 medication. Your clinician will screen for this before prescribing anything.

Question 23

Is GLP-1 microdosing right for me?

Accepted Answer

Not everyone is a candidate for an individualized lower-dose GLP-1 approach. Your clinician will evaluate your health history, treatment goals, and whether this off-label strategy is appropriate for your situation.

Question 24

Can I use GLP-1 microdosing with my Prometheuz care plan?

Accepted Answer

If clinically appropriate, your clinician may discuss whether an individualized lower-dose GLP-1 approach is suitable for your care plan. Because evidence supporting this strategy remains limited, any recommendation is based on your medical history, treatment goals, and clinician judgment.

Question 25

How long should I stay on an individualized lower-dose GLP-1 approach?

Accepted Answer

The duration varies for every patient. Your clinician will regularly review your progress and determine whether your current dose should be maintained, adjusted, or transitioned based on your treatment goals and response.

Question 26

Can I take GLP-1 microdosing with other medications?

Accepted Answer

Some medications can affect or be affected by GLP-1 therapy. During your consultation, your Prometheuz clinician will review your current medications to determine whether an individualized lower-dose GLP-1 approach may be appropriate for you.

Question 27

What are peptides?

Accepted Answer

Peptides are short chains of amino acids that signal a specific process in the body, like hormone release or a metabolic pathway, rather than replacing something outright.

Question 28

How do peptides work?

Accepted Answer

Each compound works differently. Sermorelin binds a receptor on the pituitary gland to trigger GH release; NAD+ participates directly in cellular energy production; B12-MIC supports methylation and fat metabolism.

Question 29

Do I automatically get a peptide prescription after the assessment?

Accepted Answer

No. A US-licensed clinician reviews your labs and health history first. If a specific compound may be appropriate for your goals, they'll recommend it. If not, they'll explain why.

Question 30

Which peptide is right for me?

Accepted Answer

That depends on your labs and goals. Sleep and recovery concerns are often discussed alongside Sermorelin, general energy and perceived mental clarity alongside NAD+, and suspected B12 deficiency alongside B12-MIC. Your clinician makes the final call.

Question 31

Who should avoid peptide therapy?

Accepted Answer

Patients who are pregnant or breastfeeding, have an active malignancy, or have a pituitary condition (for Sermorelin specifically) are generally not candidates. Diabetes, thyroid, kidney, or liver disease, and current medications, are also reviewed before prescribing.

Question 32

Are any of these peptides FDA-approved?

Accepted Answer

No, not for these uses. Sermorelin's original branded version had a narrow pediatric approval that was discontinued in 2008. B12 is FDA-approved for treating diagnosed deficiency, but the B12-MIC combination is off-label. NAD+ is not FDA-approved for any indication.

Question 33

How is peptide therapy different from hormone replacement therapy?

Accepted Answer

Testosterone replacement therapy (TRT) directly replaces a clinically low hormone. Sermorelin instead signals the pituitary gland to release more of your own growth hormone, rather than supplying a hormone directly.

Question 34

What's the difference between NAD+ and Sermorelin?

Accepted Answer

NAD+ acts inside cells to support energy production and metabolic pathways. Sermorelin acts on the pituitary gland to influence hormone signaling. They target different systems and are typically considered for different goals.

Question 35

Is peptide therapy different from a B12 or vitamin injection?

Accepted Answer

B12-MIC is closer to a vitamin/lipotropic injection than the other two compounds. NAD+ and Sermorelin work through cellular and hormonal signaling pathways rather than correcting a nutrient deficiency.

Question 36

How often are injections given, and how long does therapy last?

Accepted Answer

This depends on the compound and your clinician's plan; medication ships every 4 weeks. There's no fixed end date. Continuing, adjusting, or stopping is reviewed at quarterly monitoring visits based on your response.

Question 37

How should peptides be stored?

Accepted Answer

Your clinician and pharmacy provide compound-specific storage instructions when your medication ships, since requirements vary (some require refrigeration).

Question 38

What happens if I stop therapy?

Accepted Answer

Effects tied to ongoing signaling, like Sermorelin's influence on GH release, typically fade once you stop. This is discussed with your clinician as part of your monitoring plan.

Question 39

Can I take more than one peptide at once?

Accepted Answer

Combining peptides happens only under clinician guidance, based on your labs and goals, not as a default bundle.

Question 40

Will insurance cover this?

Accepted Answer

Usually not, since these are off-label, compounded, cash-pay treatments. FDA-approved uses, like B12 for a diagnosed deficiency, are more likely to have a coverage pathway elsewhere.

Question 41

How long before I'd notice a difference?

Accepted Answer

This varies by compound and by what you're tracking. Response varies considerably between individuals, and no established timeline applies to everyone.

Question 42

Why does Sermorelin have an age requirement?

Accepted Answer

Sermorelin is available to patients aged 25 and older only, under the Prometheuz clinical intake protocol, reflecting where growth hormone baselines are more established.

Question 43

How much does Prometheuz cost?

Accepted Answer

Membership plans start at $139 per month on the annual plan and go up to $199 per month on the monthly plan. There is a one-time $50 lab and consultation fee that covers your initial bloodwork and first clinician overview. After that, your membership covers your online clinician care, prescription management, medication, and quarterly monitoring. There are no hidden fees. If you are not eligible for TRT, your fee will be refunded.

Question 44

What's included in my membership?

Accepted Answer

Your membership covers your US-licensed online clinician, your TRT prescription when clinically appropriate, medication management, quarterly follow-up appointments, PSA and hematocrit monitoring, and secure messaging with your care team. Higher-tier plans include additional protocol reviews, supplement discounts, priority scheduling, and rate locks. A full breakdown of what's included in each plan is on our pricing page.

Question 45

Can I cancel anytime?

Accepted Answer

Yes. You can cancel your subscription at any time by contacting our support team at support@prometheuz.com. To avoid being charged for the next billing cycle, submit your cancellation request at least 72 hours before your next billing date. Cancellation stops future charges but does not entitle you to a refund for amounts already billed. Lab fees and pharmacy charges are non-refundable once services have been completed.

Question 46

Does Prometheuz accept insurance?

Accepted Answer

Prometheuz is a cash-pay platform and does not bill insurance directly. Most specialized online TRT clinics operate this way: insurance billing adds prior authorizations, coverage denials, and delays that slow your care down significantly. Your membership fee covers everything in one flat rate. We provide itemized receipts that you can submit to your insurer for potential out-of-network reimbursement, and HSA and FSA funds can typically be used toward your membership and lab costs.

Question 47

Who are the clinicians treating me?

Accepted Answer

All clinical care at Prometheuz is provided by independent, US-licensed physicians and nurse practitioners who are credentialed through their state medical boards and registered with the DEA (required for prescribing testosterone, which is a Schedule III controlled substance). After you complete your assessment and lab work, you're matched with a licensed clinician online for your appointment. You choose your appointment time from available slots in your patient portal once you purchase a membership plan.

Question 48

Are my health records secure?

Accepted Answer

Yes. All health information on the Prometheuz platform is protected under HIPAA, the federal law that governs the privacy and security of medical records. Your data is encrypted in transit and at rest, access-controlled, and never sold to third parties. Your health records are shared only with the clinicians involved in your care, lab partners processing your bloodwork, and pharmacies fulfilling your prescriptions, exactly as required to provide your treatment.

Question 49

Is Prometheuz HIPAA compliant?

Accepted Answer

Yes. Prometheuz is fully HIPAA compliant. Your Protected Health Information (including your lab results, health history, and clinical notes) is handled in accordance with the HIPAA Privacy Rule and Security Rule. You have the right to access your records, request corrections, and receive an accounting of how your information has been disclosed. For questions about your privacy rights or to make a request, contact our Privacy Team at privacy@prometheuz.com.

Question 50

What happens to my medical records if I cancel?

Accepted Answer

Your medical records are retained as required by applicable state and federal law, typically a minimum of seven years for adult patients. You retain the right to access your records at any time after cancellation by contacting privacy@prometheuz.com. Cancellation ends your access to the patient portal and clinical services but does not result in deletion of your health records. If you ever return to Prometheuz, your history is on file.